Tissue-engineered blood vessel mimics in complex geometries for intravascular device testing

Tissue-engineered vascular grafts as in vitro blood vessel mimics for the evaluation of endothelialization of intravascular devices.

The accelerating use of minimally invasive procedures for the treatment of cardiovascular disease, and the commensurate development of intravascular devices such as stents, has lead to a high demand for preclinical assessment techniques. A 3-dimensional in vitro blood vessel mimic (BVM) would be ideal for device testing before animal or clinical studies. This is possible based on current capabi...

Development and Implementation of Assessment Methods for Tissue-Engineered Blood Vessel Mimics

Tissue-engineered blood vessel for adult arterial revascularization.

With the rise in obesity and heart disease in the United States and around the world, there is a strong correlation with the need to develop various ways to repair damaged blood vessels. Previous treatments of the repair of blood vessels involved stents and also various forms of synthetic sheaths. However, these treatments had their problems. Problems included movement of the stent, blood clott...

Manufacturing and Mechanical Testing of Biochemically Stimulated Tissue-engineered Blood Vessel Constructs

Decellularized tissue-engineered blood vessel as an arterial conduit.

Arterial tissue-engineering techniques that have been reported previously typically involve long waiting times of several months while cells from the recipient are cultured to create the engineered vessel. In this study, we developed a different approach to arterial tissue engineering that can substantially reduce the waiting time for a graft. Tissue-engineered vessels (TEVs) were grown from ba...